Multisensory Training Improves Auditory Spatial Processing following Bilateral Cochlear Implantation

Cochlear implants (CIs) partially restore hearing to the deaf by directly stimulating the inner ear. In individuals fitted with CIs, lack of auditory experience due to loss of hearing before language acquisition can adversely impact outcomes. For example, adults with early-onset hearing loss generally do not integrate inputs from both ears effectively when fitted with bilateral CIs (BiCIs). Here, we used an animal model to investigate the effects of long-term deafness on auditory localization with BiCIs and approaches for promoting the use of binaural spatial cues. Ferrets were deafened either at the age of hearing onset or as adults. All animals were implanted in adulthood, either unilaterally or bilaterally, and were subsequently assessed for their ability to localize sound in the horizontal plane. The unilaterally implanted animals were unable to perform this task, regardless of the duration of deafness. Among animals with BiCIs, early-onset hearing loss was associated with poor auditory localization performance, compared with late-onset hearing loss. However, performance in the early-deafened group with BiCIs improved significantly after multisensory training with interleaved auditory and visual stimuli. We demonstrate a possible neural substrate for this by showing a training-induced improvement in the responsiveness of auditory cortical neurons and in their sensitivity to interaural level differences, the principal localization cue available to BiCI users. Importantly, our behavioral and physiological evidence demonstrates a facilitative role for vision in restoring auditory spatial processing following potential cross-modal reorganization. These findings support investigation of a similar training paradigm in human CI users

Children's Perception of Speaker Identity from Spectrally Degraded Input

Speaker identification is a challenge for cochlear implant users because their prosthesis restricts access to the cues that underlie natural voice quality. The present thesis examined speaker recognition in the context of spectrally degraded sentences. The listeners of interest were child implant users who were prelingually deaf as well as hearing children and adults who listened to speech via vocoder simulations of implant processing. Study 1 focused on child implant users' identification of a highly salient speaker—the mother (identified as mother)—and unfamiliar speakers varying in age and gender (identified as man, woman, or girl). In a further experiment, children were required to differentiate their mother's voice from the voices of unfamiliar women. Young hearing children were tested on the same tasks and stimuli. Although child implant users performed more poorly than hearing children overall, they successfully differentiated their mother's voice from other voices. In fact, their performance surpassed expectations based on previous studies of child and adult implant users. Even when natural variations in speaking style were reduced, child implant users successfully identified the speakers. The findings imply that person-specific differences in articulatory style contributed to implanted children's successful performance. Study 2 used vocoder simulations of cochlear implant processing to vary the spectral content of sentences produced by the man, woman, and girl from Study 1. The ability of children (5-7 years and 10-12 years) and adults with normal hearing to identify the speakers was affected by the level of spectral degradation and by the gender of the speaker. Female voices were more difficult to identify than was the man's voice, especially for the younger children. In some respects, hearing individuals' identification of degraded voices was poorer than that of child implant users in Study 1. In a further experiment, hearing children and adults were required to provide verbatim repetitions of spectrally degraded sentences. Their performance on this task greatly exceeded their performance on speaker identification at comparable levels of spectral degradation. The present findings underline the importance of ecologically valid materials and methods when assessing speaker identification, especially in children. Moreover, they raise questions about the efficacy of vocoder models for the study of speaker identification in cochlear implant users.Ph

Multimodal and Spectral Degradation Effects on Speech and Emotion Recognition in Adult Listeners

For cochlear implant (CI) users, degraded spectral input hampers the understanding of prosodic vocal emotion, especially in difficult listening conditions. Using a vocoder simulation of CI hearing, we examined the extent to which informative multimodal cues in a talker’s spoken expressions improve normal hearing (NH) adults’ speech and emotion perception under different levels of spectral degradation (two, three, four, and eight spectral bands). Participants repeated the words verbatim and identified emotions (among four alternative options: happy, sad, angry, and neutral) in meaningful sentences that are semantically congruent with the expression of the intended emotion. Sentences were presented in their natural speech form and in speech sampled through a noise-band vocoder in sound (auditory-only) and video (auditory–visual) recordings of a female talker. Visual information had a more pronounced benefit in enhancing speech recognition in the lower spectral band conditions. Spectral degradation, however, did not interfere with emotion recognition performance when dynamic visual cues in a talker’s expression are provided as participants scored at ceiling levels across all spectral band conditions. Our use of familiar sentences that contained congruent semantic and prosodic information have high ecological validity, which likely optimized listener performance under simulated CI hearing and may better predict CI users’ outcomes in everyday listening contexts

Bilateral cochlear implantation in the ferret: A novel animal model for behavioral studies

Bilateral cochlear implantation has recently been introduced with the aim of improving both speech perception in background noise and sound localization. Although evidence suggests that binaural perception is possible with two cochlear implants, results in humans are variable. To explore potential contributing factors to these variable outcomes, we have developed a behavioral animal model of bilateral cochlear implantation in a novel species, the ferret. Although ferrets are ideally suited to psychophysical and physiological assessments of binaural hearing, cochlear implantation has not been previously described in this species. This paper describes the techniques of deafening with aminoglycoside administration, surgical implantation of an intracochlear array and chronic intracochlear electrical stimulation with monitoring for electrode integrity and efficacy of stimulation. Experiments have been presented elsewhere to show that the model can be used to study behavioral and electrophysiological measures of binaural hearing in chronically implanted animals. This paper demonstrates that cochlear implantation and chronic intracochlear electrical stimulation are both safe and effective in ferrets, opening up the possibility of using this model to study potential protective effects of bilateral cochlear implantation on the developing central auditory pathway. Since ferrets can be used to assess psychophysical and physiological aspects of hearing along with the structure of the auditory pathway in the same animals, we anticipate that this model will help develop novel neuroprosthetic therapies for use in humans